The work focuses of the antifungal activity of Euphorbia sanguinea stem sap against onychomycosis causing fungi as well as its phytochemical composition and antibacterial activity. The work shows that the sap has no activity against Escherichia coli, Staphylococcus albus, Staphylococcus aureus, Proteus mirabilis, Samonela thyphi and Klebsiella pneumoniae. It contains flavonoids and saponins but lacks tannins, alkaloids, terpenoids and anthraquinones. The sap shows a strong antifungal activity when compared with the conventional antifungal agents in the market. It has activity against certain fungi responsible for onychomycosis. It is therefore a suitable natural substitute for the conventional antionychomycotic agents.